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. 2020 Dec 3;11:580223. doi: 10.3389/fphys.2020.580223

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Copyright © 2020 Dai, Xiang, Fu, Xu, Jiang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FCL. extract attenuates skeletal muscle atrophy and inhibits IL-1β and IL-6 production in denervated muscle (n = 4 mice in each group). (A,B) The wet weight ratio of gastrocnemius at 21 days post-denervation. (C,D) HE staining of muscle tissue and means ± SEM of fibro-diameter showing muscle atrophy that was reduced by FCL. extract treatment. (E,F) Compared to control group muscle, IL-1β and IL-6 positive-expression was increased in the denervated muscle of Den-saline group mice; the levels of both cytokines were lower in the Den-FCL. mice. Scale bar, 50 μm. **p < 0.01 versus Control. ##p < 0.01 versus Den-Saline.