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. 2020 Dec 3;11:597520. doi: 10.3389/fphar.2020.597520

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Copyright © 2020 Li, Han, Zhao, Guo and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Napabucasin down-regulates p-STAT3^Tyr705 and stemness markers. (A) Immunoblot showing STAT3 and p-STAT3^Tyr705 levels in Huh7 and Hepa one to six cells treated with different concentrations of napabucasin for 12 h. (B) STAT3 and stemness marker mRNAs in the suitably treated Huh7 and Hepa1-6 cells. Data were normalized to β-actin. (C) STAT3 and stemness marker expression in spheroid derived from Huh7 and Hepa1-6 cells. (D) Stemness marker expression in Huh7 or Hepa1-6 cell-derived spheres treated with indicated concentrations of napabucasin for 12 h. Data are shown as mean ± SD of three independent experiments (*P < 0.05, **P < 0.01 and ***P < 0.001).