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Napabucasin reduces cancer stem cell characteristics in hepatocellular carcinoma. Napabucasin significantly decreased the viability of HCC cells in vitro by inducing apoptosis and cell cycle arrest. In addition, it suppressed CSC-related gene expression and spheroid formation in vitro, indicating depletion of CSCs. Further, napabucasin also restricted HBV replication in HBV+ HCC cells.
