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The Nrf2 signal transduction pathway. (A) Coexpression correlation analysis in the TCGA HCC RNA-Seq cohort. (B) Following UBA1 silencing, Nrf2 expression, along with the downstream members (HO-1, NQO1, and FTH1) (C), was downregulated, as evidenced by Western blotting. (D, E) Best oltipraz dose screening. *p < 0.01, #p < 0.05.
