Table 2.
Summary of genes known to play a role in stage conversion in T. gondii.
| Gene Name | Role in stage conversion associated gene expression | Gene ID T. gondii (from Toxodb.org) | Gene ID H. hammondi ortholog(from Toxodb.org) | Gene ID N. caninum ortholog(from Toxodb.org) |
|---|---|---|---|---|
| HDAC3 | Represses transcription | TgME49_227290 | HHA_227290 | NCLIV_045860 |
| MORC | Works with HDA3 and AP2 factors to repress transcription | TgME49_305340 | HHA_305340 | NCLIV_043930 |
| GCN5-A | Activates transcriptions | TgME49_254555 | HHA_254555 | NCLIV_008840 |
| CARM1 | Activity needed to maintain tachyzoites | TgME49_294270 | HHA_294270 | NCLIV_001020 |
| SCRAP | Upregulates BAG1 expression | TgME49_280800 | HHA_280800 | NCLIV_019390 |
| RSC8 | Regulates transcription of bradyzoite genes | TgME49_286920 | HHA_286920 | NCLIV_013840 |
| H2A.Z | Expressed in bradyzoites; function in stage conversion is unknown | TgME49_300200 | HHA_300200 | NCLIV_064530 |
| H2AX | Expressed in bradyzoites; function in stage conversion is unknown | TgME49_261580 | HHA_261580 | NCLIV_025910 |
| AP2XI-4 | Promotes bradyzoite formation | TGME49_315760 | HHA_315760 | NCLIV_058430 |
| AP2IX-9 | Maintains pre-bradyzoites | TgME49_306620 | HHA_306620 | NCLIV_044800 |
| AP2IX-4 | Promotes bradyzoite formation | TgME49_288950 | HHA_288950 | NCLIV_041340 |
| AP2IV-4 | Promotes bradyzoite formation | TgME49_318470 | HHA_318470 | NCLIV_011080 |
| AP2IV-3 | Promotes bradyzoite formation | TgME49_318610 | HHA_318610 | NCLIV_010930 |
| AP2XII-4 | Interacts with MORC, maintains tachyzoites | TgME49_217700 | HHA_217700 | NCLIV_062490 |
| BFD1 | Required for bradyzoite formation | TgME49_200385 | HHA_200385 | NCLIV_038230 |
| ENO1 | Promotes bradyzoite formation | TgME49_268860 | HHA_268860 | NCLIV_037490 |
| ENO2 | Expressed in tachyzoite nuclei, function in stage conversion is unknown | TgME49_268850 | HHA_268850 | NCLIV_037500 |
| IF2a | Phosphorylated in bradyzoites, leads to increase in bradyzoite specific gene expression | TgME49_258740 | HHA_258740 | NCLIV_027770 |
| IF2K-A | Phosphorylates IF2a, activity promotes bradyzoite formation | TgME49_229630 | HHA_229630 | NCLIV_030460 |
| Alba1 | Promotes bradyzoite formation | TgME49_221380 | HHA_221380 | NCLIV_004920 |
| Alba2 | Promotes bradyzoite formation | TgME49_218820 | HHA_218820 | NCLIV_061560 |