Table 3.

Prognostic factors for any breast complication and major breast complication in patients with mastectomy.

Variable	Any breast complication						Major breast complication
	Univariate analysis			Multivariate analysis			Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age
≥ 45 (vs. <45)	1.63	1.04–2.54	0.032	1.46	0.93–2.29	0.099	2.46	1.26–5.21	0.019	2.56	1.18–5.52	0.016
Body Mass Index
≥ 23 (vs. <23)	1.55	0.99–2.43	0.055	1.41	0.89–2.23	0.147	2.08	0.98–4.42	0.057	1.98	0.91–4.34	0.087
Reconstruction type
Implant (vs. Autologous)	1.24	0.80–1.94	0.337	–	–	–	1.84	0.88–3.87	0.106	2.23	1.03–4.81	0.041
Neoadjuvant chemotherapy
Yes (vs. No)	0.82	0.53–1.29	0.391	–	–	–	0.95	0.46–1.97	0.892	–	–	–
Adjuvant chemotherapy
Yes (vs. No)	1.41	0.90–2.20	0.134	1.21	0.77–1.92	0.408	1.06	0.51–2.20	0.879	–	–	–
RT technique
IMRT (vs. 3D)	0.81	0.51–1.28	0.365	–	–	–	0.75	0.35–1.63	0.468	–	–	–
RT Fractionation
Hypofractionated RT (vs. Conventional RT)	0.65	0.41–1.03	0.066	0.58	0.36–0.94	0.027	0.73	0.34–1.57	0.422	–	–	–
Tumor Bed Boost
Yes (vs. No)	0.96	0.46–1.99	0.902	–	–	–	1.72	0.66–4.51	0.269	–	–	–
Bolus
Yes (vs. No)	0.58	0.31–1.09	0.091	0.52	0.27–1.02	0.056	0.43	0.14–1.32	0.140	0.59	0.18–1.90	0.377

P-value by cox regression model.

Abbreviations: HR, hazard ratio; CI, confidence interval; IMRT, intensity-modulated radiotherapy; 3D, 3-dimensional conformal radiotherapy.