Fig. 6.

Nrf2a is essential for redox dependent disruption of β-cell morphology. Nrf2a wt/wt or Nrf2a m/m fish were exposed to water (n = 70 fish), 77.6 μM tBOOH (n = 32 fish) or 776 μM tBOOH (n = 35 fish) for 10 min at 48 hpf and their length (A), β-cell cluster area (B) and incidence of hypomorphic islets (cutoff represented by dashed line) (C) were measured at 96 hpf. Different letters indicate significantly different means across indicated group. p < 0.05 compared to respective control as determined by a 1-way ANOVA followed by a Tukey-Kramer post-hoc.