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. 2020 Dec 16;10:22023. doi: 10.1038/s41598-020-79146-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bone marrow and splenic hematopoiesis in Dahl/SS rats. Hematoxylin and eosin staining of femur bone marrow in the control and the HS groups (a). (bars 50 μm) Spleen weight (b), the percentage of HIS49 positive cells in femur bone marrow cells (c) and splenocytes (d) in the control (n = 4) and the HS (n = 5) groups. The correlation of hemoglobin levels and serum erythropoietin levels in the control (n = 7) and the HS (n = 7) groups (e). The correlation of serum erythropoietin levels and spleen weight (f), the percentage of HIS49 positive cells in femur bone marrow cells (g), and those in splenocytes (h) in the control (n = 4) and the HS (n = 5) groups. Statistical analysis was performed using unpaired Student’s t test in (b), (c), (d). The associations between two parameters were analyzed using Pearson’s correlation coefficient in (e), (f), (g) and (h) by JMP Pro Version 14.2.0 software (SAS Institute Inc.). *p < 0.05 vs. the control group.