Table 2.
Physiologic and hematologic parameters at 14–15 weeks of age.
| Parameter | Control | HS | HSDEF |
|---|---|---|---|
| Body weight (g) | 417.5 ± 8.1 | 310.2 ± 16.8* | 319.7 ± 19.4* |
| Systolic blood pressure (mmHg) | 123.3 ± 3.2 | 205.1 ± 16.2* | 224.0 ± 8.1* |
| Diastolic blood pressure (mmHg) | 100.8 ± 2.8 | 170.7 ± 15.5* | 183.0 ± 9.4* |
| Heart rate (bpm) | 414.4 ± 13.3 | 446.2 ± 32.5 | 451.5 ± 19.6 |
| Lung weight/tibia length (mg/mm) | 36.5 ± 0.8 | 36.2 ± 1.0 | 36.7 ± 1.5 |
| LV weight/tibia length (mg/mm) | 22.0 ± 0.3 | 30.1 ± 0.6* | 31.2 ± 1.2* |
| Spleen weight/tibia length (mg/mm) | 24.1 ± 1.1 | 45.6 ± 3.5* | 43.4 ± 8.1† |
| Kidney weight/tibia length (mg/mm) | 36.2 ± 0.9 | 42.9 ± 1.9* | 39.9 ± 1.9 |
| Red blood cell (× 106/μL) | 9.07 ± 0.65 | 6.34 ± 0.51* | 5.79 ± 1.04* |
| Hemoglobin (g/dL) | 15.7 ± 1.3 | 11.5 ± 0.8* | 10.2 ± 1.9* |
| Hematocrit (%) | 45.8 ± 2.3 | 39.8 ± 1.8 | 34.7 ± 4.2* |
| MCH (pg) | 17.3 ± 0.2 | 18.3 ± 0.3 | 17.5 ± 0.6 |
| MCV (fL) | 50.9 ± 1.0 | 63.7 ± 2.3* | 61.8 ± 3.7* |
| MCHC (g/dL) | 34.1 ± 0.9 | 28.8 ± 0.7* | 28.7 ± 1.9* |
| Reticulocyte (%) | 3.0 ± 0.1 | 24.3 ± 4.1* | 25.0 ± 8.5* |
| Reticulocyte (× 104/μL) | 27.2 ± 2.6 | 145.0 ± 21.7* | 120.5 ± 31.4* |
| RDW-CV (%) | 20.5 ± 0.8 | 25.1 ± 1.6* | 24.3 ± 0.9 |
| Platelet (× 104/μL) | 102.3 ± 6.7 | 96.6 ± 11.2 | 97.9 ± 22.8 |
| Creatinine (mg/dL) | 0.35 ± 0.02 | 0.68 ± 0.08* | 0.61 ± 0.07* |
| Fe (μg/dL) | 170.0 ± 12.5 | 77.0 ± 18.6* | 73.5 ± 22.6* |
| TIBC (μg/dL) | 446.2 ± 9.8 | 357.7 ± 13.9* | 365.0 ± 16.9* |
| UIBC (μg/dL) | 276.2 ± 19.9 | 280.7 ± 17.0 | 291.5 ± 34.0 |
| Total-billirubin (mg/dL) | 0.07 ± 0.01 | 0.08 ± 0.03 | 0.11 ± 0.01* |
| Indirect-billirubin (mg/dL) | 0.05 ± 0.01 | 0.06 ± 0.02 | 0.09 ± 0.01* |
| Urine volume (ml/24 h) | 16.5 ± 2.8 | 36.6 ± 0.2* | 35.8 ± 0.2* |
| Urine protein (mg/24 h) | 20.5 ± 2.4 | 120.1 ± 17.3* | 77.6 ± 15.8* |
| Urine protein/creatinine | 1.4 ± 0.2 | 23.6 ± 3.7* | 17.6 ± 4.1* |
*p < 0.05; vs. the control group, †p < 0.05; the HSDFX versus the control group.