Fig. 2.

Overview of the influences of cell metabolism, autophagy and cell migration on cancer extracellular vesicle secretion. Cancer cells can release multiple subpopulations of exosomes from different compartments including early endosomes, multivesicular bodies and amphisomes. Upper right insert: Amoeboid migration and invadopodia-mediated invasion trigger the release of distinct extracellular vesicle subsets that help the migration of tumour cells through different types of extracellular matrix. Created with BioRender.com.