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. 2020 Nov 28;47(1):6–18. doi: 10.1002/biof.1691

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© 2020 International Union of Biochemistry and Molecular Biology

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Brief overview of specialized proresolving mediator (SPM) biosynthesis and proresolving actions. SPMs are synthesized from essential polyunsaturated fatty acids via lipoxygenase enzymes and others. In infection and inflammatory lung conditions, SPMs act to resolve inflammation and improve outcomes. 14‐ and 17(S)‐HDHA, 14‐ and 17(S)‐hydroxydocosahexaenoic acid; 15(S)‐HETE, 15(S)‐hydroxyeicosatetraenoic acid; 18(R)‐HEPE, 18(R)‐hydroxyeicosapentaenoic acid; CYP450, cytochrome P450; LOX, lipoxygenase; PUFAs, polyunsaturated fatty acids