Figure 14.

a) Schematic of a piezoelectric plate sensor for Hepatitis B virus double mutation (HBVDM) detection; b) the first length‐extension mode and c) width‐extension mode vibration of the piezoelectric plate sensor, with the shaded bars indicating the initial position of the piezoelectric plate sensor and the dashed shapes illustrating the extended positions. d) Top‐view optical microscopy image and e–h) fluorescence images of the sensor obtained after fluorescent reporter microsphere detection that followed the mutation detection in a mixture of mutant with 250 times more wild type at mutation concentrations of: e) 100 × 10⁻²¹ m, f) 1 × 10⁻¹⁸ m, g) 10 × 10⁻¹⁸ m, and h) 100 × 10⁻¹⁸ m. a–h) Reproduced with permission.^{[ 94 ]} Copyright 2015, The Royal Society of Chemistry.