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. 2020 Dec 2;21(1):2000198. doi: 10.1002/pmic.202000198

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© 2020 Wiley‐VCH GmbH

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

PMC Copyright notice

Proteomics in the COVID‐19 battlefield. Examination of infected cell models and clinical samples by system‐wide unbiased discovery proteomics approaches is used to unravel the mechanisms employed by SARS‐CoV‐2 to bind, enter, hijack, and exit the host. Together with data from the SARS‐CoV‐2 profiling by mass spectrometry, these analyses provided a library of high‐quality viral peptide spectra that can be used for targeted proteomics detection. In addition, insights from the various multi‐level proteomics datasets represent a valuable resource for the identification of promising targets for therapeutic intervention. Besides, quantitative proteomics represents a promising tool to support the screening of drug repurposing libraries and for the understanding of cellular changes in metabolism occurring following initiation of anti‐SARS‐CoV‐2 treatment.