TABLE 6.

The subgroup analysis results of all grade CRS and severe CRS.

Subgroup	No of trails CRS (95% CI) p for differences	CRS≥3 (95% CI)	p for differences
Conditions
CP	3 0.8625 [0.7690; 0.9367]	0.1627 [0.0359; 0.3453]
CP/Flu	17 0.7378 [0.5771; 0.8745] 0.1105	0.1028 [0.0387; 0.1858]	0.5905
CAR-T target
BCMA	16 0.6973 [0.5124; 0.8576]	0.0836 [0.0405; 0.1646]
BCMA + CD19/bispecific BCMA	6 0.8978 [0.8196; 0.9587] 0.0225	0.1641 [0.0380; 0.4935]	0.3979
Costimulatory domain
4-1BB	20 0.7286 [0.5857; 0.8533]	0.0905 [0.0454; 0.1457]
CD28	4 0.8946 [0.5848; 1.0000] 0.306	0.2311 [0.0000; 0.6907]	0.4317