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(A) Schematic representation of modular structure of SARS-CoV S-protein and its furin cleavage sites indicated by arrows. SP = signal peptide. (B) S1 cleavage furin site on human coronaviruses, the novel sites in SARS-CoV-2 is underlined in red while the furin cleavage on MERS is italicized. (C) Typical furin cleavage site.
