Fig. 3.

Quantitative grading of DCIS using nuclear morphological features. a, Annotations categorizing each DCIS cell within a tissue to a nuclear grade based on their cross-sectional area from a H&E image. Scale bar, 20 µm. b, Average number of cells belonging to grade 1–3 within a DCIS tissue grouped by pathological grade. c, Annotations categorizing each DCIS duct within a tissue to a nuclear grade based on the worst 10% of cells according to their cross-sectional area from a H&E image. Scale bar, 1 mm. d, Average number of ducts belonging to grade 1–3 within a DCIS tissue grouped by pathological grade. For all annotations, grade 1 (light blue), 2 (medium blue), and 3 (dark blue). All plots represent grade 1, n = 12; 2, n = 34; 3, n = 44. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)