Fig. 2.

H₂S-releasing molecule, MZe786 rescued preeclamptic phenotype in mRUPP model. (A) Mean arterial blood pressure (MAP) recorded at day 17.5 of gestation of Sham or mRUPP mice treated with MZe786 or control. MAP was significantly upregulated in mRUPP mice (n = 15) compared to Sham (n = 15). MZe786 (n = 7) effectively reduced the increase in MAP induced by mRUPP. (B) Representative H&E images of kidney from different groups (scale bar represents 50 μm). Sham kidney section showed normal renal cortex and glomerular tufts. mRUPP group showed marked kidney damage including glomerular degeneration with absence of bowman's capsular space, disorganised tubules, fibrosis and vascular congestion. MZe786 treated Sham and mRUPP showed architecture similar to Sham, n = 6. (C) The graph shows the scoring of the pathological changes, n = 6. (D) Urine levels of KIM-1 in Sham or mRUPP mice treated with MZe786 or control. mRUPP induced significantly high levels of KIM-1. MZe786 treated mice showed significant reduction in KIM-1 levels, n = 6. Data expressed as mean (±SEM) and analysed by 2-way ANOVA. Clear circles represent group that received drug career and black squares represent group that received MZe786. White bars represent group that received drug career and black bars represent group that received MZe786.