Fig. 5.

MZe786 reversed altered placental morphology in mRUPP model. (A) Gross histological assessment of placental morphology showed marked reduction of placental labyrinth zone (indicated by dashed lines) in mRUPP compared to Sham (scale bar represents 1 mm). Oral administration of MZe786 significantly reduced this structural alteration induced by mRUPP. Placenta of Sham mice treated with MZe786 remain unchanged (n = 4). (B) Isolectin B4 staining of labyrinth zone showing altered vasculature in the mRUPP mice and rescue when treated with MZe786. (C) Graph showing the measurement of area of labyrinth zone using Image J software. Results are representative or expressed as mean (±SEM) and analysed by 2-way ANOVA, n = 7. White bars represent group that received drug career and black bars represent group that received MZe786.