Fig. 6.

MZe786 rescue PE phenotype in mRUPP by downregulating sFlt-1. qPCR data showing decreased CSE mRNA expression in mRUPPs compared to Sham (A). mRNA expression levels of sFlt-1 in placenta (B). ELISA data showing protein levels of sFlt-1 in amniotic fluid (C), and plasma (D). CSE mRNA expression was significantly downregulated in mRUPPs and the sFlt-1 levels were correspondingly upregulated in mRUPPs compared to Sham. MZe786 effectively lowered sFlt-1 expression in mRUPP mice. Data expressed as mean (±SEM) and analysed by 2-way ANOVA, n = 6. White bars represent group that received drug career and black bars represent group that received MZe786.