Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 3;7:598652. doi: 10.3389/fmed.2020.598652

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Zhang, Wu, Chang, Liu, Xie, Yang and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Subgroup analysis on septic population with pneumonia. (A) Violin plots of immune cell difference analyses (medians, quartiles, extremums, data distributions, and P-values for the difference analysis are described in violin plots. The percentages of immune-enhancing cells—activated neutrophils- were significantly downregulated in the immunity-A endotype. The percentages of immune suppressive cells—M2 macrophages—and naïve immune cells (naïve B cells, naïve CD4 T cells, and M0 macrophages) were obviously upregulated in the immunity-A endotype). (B) Violin plots of the immune molecule difference analysis. The immune-enhancing molecules—HLA-DRA, IL1B, IFNGR, CD5, and CD86—were significantly downregulated and the immunosuppressive molecule IL10 was obviously upregulated in the immunity-A endotype. (C) Diagrams of the Gene Set Enrichment Analysis. The innate immunity, humoral immunity, cellular immunity, and promotion of immunity-related pathways were all suppressed in the immunity-A endotype group.