Table 1.
Demographic Profile of Subjects by Study and Dose Group
| Characteristic | Single Ascending Dose Study | Volunteer Infection Study | ||||
|---|---|---|---|---|---|---|
| Placebo (n = 6) | 40 mg (n = 6) | 80 mg (n = 6) | 120 mg (n = 6) | 40 mg (n = 7) | 80 mg (n = 8) | |
| Age, y | ||||||
| Mean ± SD | 33.3 ± 11.3 | 24.8 ± 2.5 | 23.0 ± 2.6 | 40.2 ± 13.9 | 30.7 ± 8.6 | 30.9 ± 10.0 |
| Range | 19–53 | 22–28 | 21–28 | 23–53 | 23–47 | 20–48 |
| Sex, male, No. (%) | 6 (100) | 6 (100) | 6 (100) | 6 (100) | 7 (100) | 8 (100) |
| Race, No. (%) | ||||||
| White | 5 (83.3) | 5 (83.3) | 2 (33.3) | 5 (83.3) | 4 (57.1) | 8 (100) |
| Asian | 1 (16.7) | 0 (0) | 2 (33.3) | 1 (16.7) | 0 (0) | 0 (0) |
| Black | 0 (0) | 1 (16.7) | 1 (16.7) | 0 (0) | 0 (0) | 0 (0) |
| Other | 0 (0) | 0 (0) | 1 (16.7) | 0 (0) | 3 (42.9) | 0 (0) |
| BMI, kg/m2 | ||||||
| Mean ± SD | 24.1 ± 2.4 | 23.4 ± 1.9 | 24.3 ± 3.2 | 25.4 ± 3.0 | 24.3 ± 3.3 | 23.2 ± 4.4 |
| Range | 22.4–28.1 | 20.3–25.6 | 20.8–29.0 | 22.1–29.5 | 18.4–29.0 | 18.3–31.1 |
| Height, cm | ||||||
| Mean ± SD | 181.3 ± 7.7 | 182.3 ± 9.8 | 173.8 ± 9.0 | 173.8 ± 4.4 | 182.9 ± 6.4 | 182.0 ± 7.1 |
| Range | 174.0–194.0 | 172.0–198.0 | 164.0–188.0 | 170.0–181.0 | 172.0–191.0 | 173.0–192.0 |
| Weight, kg | ||||||
| Mean ± SD | 79.0 ± 7.1 | 78.1 ± 12.1 | 73.6 ± 12.0 | 76.9 ± 11.0 | 81.2 ± 11.4 | 77.3 ± 16.9 |
| Range | 67.9–85.1 | 64.4–95.2 | 58.7–95.1 | 66.2–92.7 | 58.8–92.6 | 56.0–101.9 |
Abbreviations: BMI, body mass index; SD, standard deviation.