Figure 3.

Plasma biomarker levels measured serially in patients stratified by clinical endpoints. A–B, Mean values of log10-transformed concentration of each plasma marker per time point were calculated for the entire population and also per clinical outcomes. Biomarker values were z-score normalized and illustrated in a heatmap in which biomarkers were grouped using hierarchical clustering (Ward’s method with 100× bootstrap). Dendrograms represent Euclidean distance. Abbreviation: SD, standard deviation; TB, tuberculosis.