Table 2.

Associations between DNA repair genetic aberrations and tumor mutational burden.

TMB status	Total	Direct Only	Caretaker Only	Both	Neither	P-value
	N = 760 (%)	N = 52(%)	N = 419(%)	N = 57(%)	N = 232(%)
TMB-L	611 (80.4%)	44 (84.6%)	326 (77.8%)	35 (61.4%)	206 (88.8%)	0.2
TMB-I	140 (18.4%)	7 (13.5%)	89 (21.2%)	18 (31.6%)	26 (11.2%)	0.004
TMB-H	9 (1.2%)	1 (1.9%)	4 (0.95%)	4 (7.02%)	0.00%	0.0002

TMB tumor mutational burden, TMB-H high TMB (≥ 19.5 mut/mb), TMB-I intermediate TMB (5.5–19.5 mut/mb), TMB-L low TMB (< 5.5 mut/mb).