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. 2020 Dec 16;10:22072. doi: 10.1038/s41598-020-78793-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of markers for TB progression. (A) Heatmap of seven gene expression levels of TB (red) and LTBI (green) subjects. (B) PCA score plot of TB and LTBI subjects. (C) Volcano plot showing the distribution of the gene expression fold changes in TB patients relative to LTBI. Genes with absolute fold change ≥ 4 and p-value ≤ 0.05 are indicated in orange. Expression levels are scaled from dark blue (low expression) to dark red (high expression). Figures were generated with R (version 3.6.3) using ComplexHeatmap package (version 2.0.0, https://bioconductor.org/packages/release/bioc/html/ComplexHeatmap.html), prcomp function from stats package (version 3.6.3, https://www.r-project.org/), and NanoStringNorm package (version 1.2.1.1, https://cran.r-project.org/web/packages/NanoStringNorm/index.html) for heatmap, pca and Volcano plot, respectively.