Table 2.

ROC analysis, sensibility and specificity of candidate genes to TB diagnosis.

Gene	ROC AUC (95% CI)	ROC p-value	Sensitivity % (95% CI)	Specificity % (95% CI)	Cut-off
C1QA	0.98 (0.95–1.02)	< 0.0001	88.24 (63.56–98.54)	100 (66.37–100)	> 3.74
CD274	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 5.71
CD59	0.98 (0.95–1.02)	< 0.0001	94.12 (71.31–99.85)	100 (66.37–100)	> 8.63
CEACAM1	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 6.02
CR1	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 10.02
FCGR1A/B	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 7.83
ICAM1	0.98 (0.95–1.02)	< 0.0001	88.24 (63.56–98.54)	100 (66.37–100)	> 7.54
IFITM1	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 12.86
IL18RAP	0.98 (0.95–1.02)	< 0.0001	88.24 (63.56–98.54)	100 (66.37–100)	> 8.97
IL4R	0.98 (0.95–1.02)	< 0.0001	94.12 (71.31–99.85)	100 (66.37–100)	> 9.08
IRAK3	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 6.86
JAK2	0.99 (0.97–1.01)	< 0.0001	94.12 (71.31–99.85)	100 (66.37–100)	> 9.86
JAK3	0.99 (0.97–1.01)	< 0.0001	94.12 (71.31–99.85)	100 (66.37–100)	> 8.59
LILRA5	0.97 (0.92–1.02)	< 0.0001	88.24 (63.56–98.54)	100 (66.37–100)	> 9.87
LILRA6	1.00	< 0.0001	100 (80.49–100)	100 (66.37–100)	> 7.79
LY96	0.99 (0.97–1.01)	< 0.0001	94.12 (71.31–99.85)	100 (66.37–100)	> 7.69
MAPK14	1.00	0.0008757	100 (80.49–100)	100 (47.82–100)	> 10.03
NOD2	0.92 (0.81–1.04)	0.004259	82.35 (56.57–96.20)	100 (47.82–100)	> 8.79
PDCD1LG2	1.00	0.0008757	100 (80.49–100)	100 (47.82–100)	> 4.13
PML	0.98 (0.95–1.02)	0.001156	94.12 (71.31–99.85)	100 (47.82–100)	> 7.72
SOCS3	0.96 (0.88–1.04)	0.001981	94.12 (71.31–99.85)	100 (47.82–100)	> 7.40
TAP1	0.97 (0.92–1.03)	0.001518	88.24 (63.56–98.54)	100 (47.82–100)	> 8.63
TNFAIP6	0.98 (0.95–1.02)	0.001156	94.12 (71.31–99.85)	100 (47.82–100)	> 6.02