Table 4.
Annotation of selected genes based on ROC curve analysis.
| Symbol | Name | Annotation | Target for |
|---|---|---|---|
| C1QA | Complement C1q A chain | Complement system, host pathogen interaction, innate immune system | TB diagnosis |
| C1QB | Complement C1q B chain | Complement system, host pathogen interaction, innate immune system | TB progression |
| C2 | Complement component 2 | Complement system, host pathogen interaction, innate immune system | TB progression |
| CCR2 | C–C chemokine receptor type 2 | Chemokine signaling, cytokine signaling, innate immune system, lymphocyte activation | TB progression |
| CCRL2 | C–C chemokine ligand type 2 | Chemokine signaling | TB progression |
| CD59 | CD59 molecule | Complement system, innate immune system, lymphocyte activation | TB diagnosis |
| CD274 | CD274 molecule | Adaptive immune system, cell adhesion, lymphocyte activation | TB diagnosis |
| CEACAM1 | CEA cell adhesion molecule 1 | Hemostasis, innate immune system and lymphocyte activation | TB diagnosis |
| CR1 | Complement receptor type 1 | Complement system, host pathogen interaction, innate immune system | TB diagnosis |
| FCGR1A/B | Fc fragment of IgG receptor Ia | Adaptive immune system, cytokine signaling, host pathogen interaction, innate immune system, MHC class I antigen presentation, phagocytosis and degradation and Type II interferon signaling | TB diagnosis |
| ICAM1 | Intercellular adhesion molecule 1 | Adaptive immune system, cell adhesion, innate immune system, lymphocyte activation | TB diagnosis |
| IFITM1 | Interferon induced transmembrane protein 1 | Adaptive immune system, B cell receptor signaling, cytokine signaling and Type I interferon signaling | TB diagnosis |
| IL18RAP | Interleukin 18 receptor accessory protein | Cytokine signaling, oxidative stress | TB diagnosis |
| IL4R | Interleukin 4 receptor | Cytokine signaling, lymphocyte activation and Th2 differentiation | TB diagnosis |
| IRAK3 | Interleukin 1 receptor associated kinase 3 | Cytokine signaling, innate immune system and TLR signaling | TB diagnosis |
| JAK2 | Janus kinase 2 | Chemokine signaling, cytokine signaling, host pathogen interaction, hemostasis, oxidative stress, Th1 and Th17 differentiation, Type II interferon signaling | TB diagnosis |
| JAK3 | Janus kinase 3 | Chemokine signaling, cytokine signaling, host pathogen interaction, hemostasis, lymphocyte activation, Th2 and Th17 differentiation | TB diagnosis |
| LILRA5 | Leukocyte immunoglobulin like receptor A5 | Adaptive immune system | TB diagnosis |
| LILRA6 | Leukocyte immunoglobulin like receptor A6 | Adaptive immune system and MHC class I antigen presentation | TB diagnosis |
| LILRB4 | Leukocyte immunoglobulin like receptor B4 | Adaptive immune system | TB progression |
| LY96 | Lymphocyte antigen 96 | Adaptive immune system, apoptosis, host pathogen interaction, innate immune system, MHC class I antigen presentation, NF-κB signaling, TLR signaling | TB diagnosis |
| MAPK14 | Mitogen-activated protein kinase 14 | Cytokine signaling, hemostasis, host pathogen interaction, innate immune system, lymphocyte trafficking, NLR signaling, T cell receptor signaling, Th17 differentiation, TNF family signaling and TLR signaling | TB diagnosis and TB progression |
| NOD 2 | Nucleotide binding oligomerization domain containing 2 | Cytokine signaling, host pathogen interaction, innate immune system, lymphocyte activation, NLR signaling, TNF family signaling, TLR signaling | TB diagnosis |
| MSR1 | Macrophage scavenger receptor 1 | Phagocytosis and degradation | TB progression |
| PDCD1LG2 | Programmed cell death 1 ligand 2 | Adaptive immune system, cell adhesion and lymphocyte activation | TB diagnosis |
| PML | Promyelocytic leukemia | Cytokine signaling, host pathogen interaction, oxidative stress, Type II interferon signaling | TB diagnosis |
| SOCS3 | Suppressor of cytokine signaling 3 | Adaptive immune system, cytokine signaling, host pathogen interaction, MHC class I antigen presentation, TNF family signaling, Type I interferon signaling and Type II interferon signaling | TB diagnosis |
| TAP1 | Transporter 1, ATP binding cassette subfamily B member | Adaptive immune system, host pathogen interaction, MHC class I antigen presentation, phagocytosis and degradation | TB diagnosis |
| TNFAIP6 | Tumor necrosis factor alpha induced protein 6 | Innate immune system | TB diagnosis |
TB Tuberculosis, LTBI latent tuberculosis infection.