Table 2.
Loading of top brain regions in the joint component related to AFD < 21 in the HCP subsample. A total of 24 brain regions and morphological measures in the joint component showing a loading of larger than 0.100 are listed based on the order of the magnitudes of the loadings. The results from individual linear mixed regression analyses are also listed.
| Shape | ROI | Loading | Estimate | Std. Error | P-value | P-adj. |
|---|---|---|---|---|---|---|
| Joint component | 0.06 | 0.02 | 0.001 | 0.016 | ||
| SC Vol | Brain stem | 0.434 | −81.41 | 234.73 | 0.729 | 1 |
| SC Vol | L_Thalamus proper | 0.193 | 78.82 | 90.51 | 0.385 | 1 |
| GM Vol | L_Superior frontal | 0.178 | 499.14 | 259.03 | 0.055 | 1 |
| GM Vol | R_Superior frontal | 0.171 | 397.00 | 257.66 | 0.125 | 1 |
| Area | L_Superior frontal | 0.169 | 48.00 | 81.38 | 0.556 | 1 |
| SC Vol | R_Thalamus proper | 0.161 | 109.51 | 76.38 | 0.153 | 1 |
| Area | R_Superior frontal | 0.161 | 38.85 | 80.91 | 0.632 | 1 |
| Area | R_Rostral middle frontal | 0.144 | 58.63 | 79.71 | 0.463 | 1 |
| GM Vol | R_Rostral middle frontal | 0.142 | 449.90 | 238.24 | 0.060 | 1 |
| Area | L_Rostral middle frontal | 0.137 | 5.91 | 77.23 | 0.939 | 1 |
| GM Vol | L_Rostral middle frontal | 0.137 | 172.54 | 235.32 | 0.464 | 1 |
| Area | R_Inferior parietal | 0.125 | 12.88 | 80.50 | 0.873 | 1 |
| GM Vol | R_Inferior parietal | 0.124 | 252.43 | 236.13 | 0.286 | 1 |
| Area | L_Inferior parietal | 0.113 | −61.34 | 68.54 | 0.372 | 1 |
| Area | L_Superior parietal | 0.112 | 75.94 | 68.06 | 0.265 | 1 |
| GM Vol | R_Middle temporal | 0.111 | 3.98 | 156.81 | 0.980 | 1 |
| Area | R_Superior parietal | 0.109 | 111.45 | 70.26 | 0.114 | 1 |
| GM Vol | L_Inferior parietal | 0.109 | −13.00 | 202.65 | 0.949 | 1 |
| SC Vol | R_Putamen | 0.106 | 157.07 | 57.69 | 0.007 | 0.165 |
| GM Vol | L_Inferior temporal | 0.105 | 295.26 | 186.85 | 0.115 | 1 |
| GM Vol | R_Precentral | 0.103 | 339.72 | 166.59 | 0.042 | 0.974 |
| Area | L_Supramarginal | 0.101 | 27.58 | 56.56 | 0.626 | 1 |
| Area | R_Lateral occipital | 0.101 | 10.65 | 64.34 | 0.869 | 1 |
| Area | R_Precentral | 0.101 | 60.21 | 55.14 | 0.276 | 1 |
Abbreviations: ROI, region-of-interest; L, left; R, right. SC Vol, subcortical volume; GM Vol, grey matter volume; Area, surface area. SE, standard error. P-value and P-adj. represent the p-values from the linear mixed regression models without and with multiple comparison adjustment, respectively. P-adj. was calculated based on FDR adjustment on these 24 tests.