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. 2020 Apr 18;10(12):2339–2347. doi: 10.1016/j.apsb.2020.04.003

Table 2.

Metabolic stability of 10–12, 13·HCl and 14·3HCl in rat liver microsomes.Image 7

Compd. t1/2 (min)a CLint [mL/(min·g·protein)]b
10 2.1 999.4
11 1.5 1390
12 11 198.1
13·3HCl 16 127.7
14·3HCl 25 85.1
a

t1/2: elimination half-life.

b

CLint: intrinsic body clearance.