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. 2020 Aug 3;10(12):2404–2416. doi: 10.1016/j.apsb.2020.07.018

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© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Cell viabilities of (A) A549 cells and (B) Calu-3 cells after incubated with various concentrations of ketoprofen, CD-MOF, CD-MOF-K for 24 h (data are expressed as mean ± SD, n = 6). (C) Hemolysis ratios of CF, CD-MOF, CD-MOF-K at various concentrations (data are expressed as mean ± SD, n = 3). (D) Illustration of intratracheally administration of samples to rats and the evaluation of lung function of rats. The (E) R_l and (F) C_dyn values of rats after pulmonary delivery of different samples for 1 and 8 h (data are expressed as mean ± SD, n = 6).