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. 2020 Jun 19;10(12):2384–2403. doi: 10.1016/j.apsb.2020.06.006

Figure 6.

Figure 6

(A) Pharmacokinetics of CDDP, DZ(1:1)@PEG and DZ(1:1)@ALN in SD rats from 0 to 24 h after intravenous injection. Values were represented as mean ± SD (n = 3). (B) Fluorescence quantitative assessment of major organs, healthy legs, and metastatic legs collected at 24 h post-injection. (C) Fluorescence quantitative assessment of metastatic legs collected at 24 h post-injection. (D) Metastatic leg:liver ratios quantified by DiR fluorescence at 24 h post-injection. (E) In vivo imaging of free DiR, DiR labeled DZ(1:1)@PEG and DZ(1:1)@ALN after vein injection to bone metastatic BALB/c-nu/nu mice. (F) Ex vivo fluorescence images of major organs, healthy leg, and bone metastatic leg of the representative mice after 24 h injection. (G) Fluorescence images of metastatic legs. Values were presented as mean ± SD (n = 3, ∗∗∗P < 0.001).