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. 2020 Jun 19;10(12):2384–2403. doi: 10.1016/j.apsb.2020.06.006

Figure 9.

Figure 9

Evaluation of osteolysis inhibition. (A) 3D micro-CT reconstruction image of the mice tibias. The architecture parameters of (B) BV/TV, (C) Tb.N and (D) BS/TV after various treatments (1: PBS; 2: CDDP+ZOL; 3: DSP@ALN; 4: ZOL@ALN; 5: DZ(1:1)@PEG; 6: DSP@ALN+ZOL@ALN; 7: DZ(1:1)@ALN and 8: Normal). (E) H&E and TRAP staining of the tumor-bearing tibias. B represents bone and T represents tumor. Scale bar was 200 and 100 μm for H&E and TRAP, respectively. Values were presented as mean ± SD (n = 6, **P < 0.01, ***P < 0.001).