Table 3. Vaccine Efficacy Overall and by Subgroup in Participants without Evidence of Infection before 7 Days after Dose 2.
| Efficacy End-Point Subgroup |
BNT162b2 (N=18,198) |
Placebo (N=18,325) |
Vaccine Efficacy, % (95% CI)† |
||
|---|---|---|---|---|---|
| No. of Cases |
Surveillance Time (No. at Risk)* |
No. of Cases |
Surveillance Time (No. at Risk)* |
||
| Overall | 8 | 2.214 (17,411) | 162 | 2.222 (17,511) | 95.0 (90.0–97.9) |
| Age group | |||||
| 16 to 55 yr | 5 | 1.234 (9,897) | 114 | 1.239 (9,955) | 95.6 (89.4–98.6) |
| >55 yr | 3 | 0.980 (7,500) | 48 | 0.983 (7,543) | 93.7 (80.6–98.8) |
| ≥65 yr | 1 | 0.508 (3,848) | 19 | 0.511 (3,880) | 94.7 (66.7–99.9) |
| ≥75 yr | 0 | 0.102 (774) | 5 | 0.106 (785) | 100.0 (−13.1–100.0) |
| Sex | |||||
| Male | 3 | 1.124 (8,875) | 81 | 1.108 (8,762) | 96.4 (88.9–99.3) |
| Female | 5 | 1.090 (8,536) | 81 | 1.114 (8,749) | 93.7 (84.7–98.0) |
| Race or ethnic group‡ | |||||
| White | 7 | 1.889 (14,504) | 146 | 1.903 (14,670) | 95.2 (89.8–98.1) |
| Black or African American | 0 | 0.165 (1,502) | 7 | 0.164 (1,486) | 100.0 (31.2–100.0) |
| All others | 1 | 0.160 (1,405) | 9 | 0.155 (1,355) | 89.3 (22.6–99.8) |
| Hispanic or Latinx | 3 | 0.605 (4,764) | 53 | 0.600 (4,746) | 94.4 (82.7–98.9) |
| Non-Hispanic, non-Latinx | 5 | 1.596 (12,548) | 109 | 1.608 (12,661) | 95.4 (88.9–98.5) |
| Country | |||||
| Argentina | 1 | 0.351 (2,545) | 35 | 0.346 (2,521) | 97.2 (83.3–99.9) |
| Brazil | 1 | 0.119 (1,129) | 8 | 0.117 (1,121) | 87.7 (8.1–99.7) |
| United States | 6 | 1.732 (13,359) | 119 | 1.747 (13,506) | 94.9 (88.6–98.2) |
*
Surveillance time is the total time in 1000 person-years for the given end point across all participants within each group at risk for the end point. The time period for Covid-19 case accrual is from 7 days after the second dose to the end of the surveillance period.
†
The confidence interval (CI) for vaccine efficacy is derived according to the Clopper–Pearson method, adjusted for surveillance time.
‡
Race or ethnic group was reported by the participants. “All others” included the following categories: American Indian or Alaska Native, Asian, Native Hawaiian or other Pacific Islander, multiracial, and not reported.