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. 2020 Jul 16;23(11):713–720. doi: 10.1093/ijnp/pyaa049

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© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — (A) Scatter plot of cerebrospinal fluid (CSF) levels of matrix metalloproteinases (MMP)-2 in healthy controls (HC), and in major depressive disorder (MDD) and schizophrenia (SCZ). The horizontal bars represent mean values adjusted for age and sex. *P < .05. (B) Cerebrospinal fluid (CSF) levels of MMP-2 in patients with major depressive disorder (MDD) and schizophrenia (SCZ) were significantly higher than those of healthy controls (HC). Linear regression analysis adjusted for age and sex. *P < .05. (C) Correlation between cerebrospinal fluid (CSF) levels of MMP-2 and clinical symptomatic scores in major depressive disorder (MDD) and schizophrenia (SCZ). The correlation coefﬁcients were calculated using linear regression analysis and adjusted for age and sex. *P < .05. (1) Between CSF levels of MMP-2 and the Hamilton Rating Scale for Depression (HAMD) scores in MDD. (2) Between CSF levels of MMP-2 and the Positive and Negative Syndrome Scale (PANSS) scores in SCZ.