Table 2.
Multivariate Linear Regression Analyses Between CSF Levels of MMP-7, -8, and -10, and Diagnosis
| Nonstandardized Coefficient β (pg/mL) | (95% CI) | P value | |
|---|---|---|---|
| (A) MMP-7 levels | |||
| Constant | −0.858 | (−5.069~3.354) | .689 |
| HC (n = 106) (Base) | 0 | ||
| MDD (n = 90) | 2.551 | (0.051~5.051) | .046* |
| SCZ (n = 86) | 1.202 | (−1.331~3.735) | .351 |
| Age | 0.230 | (0.147~0.313) | <.001*** |
| Sex (male) | 3.174 | (1.066~5.282) | .003** |
| R2 = 0.111, ANOVA P < .001***. | |||
| (B) MMP-8 levels | |||
| Constant | 17.196 | (10.945~23.446) | <.001*** |
| HC (n = 106) (Base) | 0 | ||
| MDD (n = 90) | -0.496 | (-4.207~3.215) | .793 |
| SCZ (n = 86) | -0.893 | (-4.653~2.867) | .641 |
| Age | 0.012 | (-0.112~0.135) | .854 |
| Sex (male) | 0.067 | (-3.062~3.196) | .966 |
| R 2 = 0.001, ANOVA P < .992. | |||
| (C) MMP-10 levels | |||
| Constant | 3.788 | (-4.839~12.416) | .388 |
| HC (n = 106) (Base) | 0 | ||
| MDD (n = 90) | 7.334 | (2.212~12.456) | .005** |
| SCZ (n = 86) | 4.507 | (-0.683~9.697) | .088 |
| Age | 0.312 | (0.142~0.482) | <.001*** |
| Sex (male) | 8.062 | (3.744~12.381) | <.001*** |
| R 2 = 0.089, ANOVA P < .001***. |
Abbreviations: CSF, cerebrospinal fluid; HC, healthy controls; MDD, major depressive disorder; MMP, matrix metalloproteinase; SCZ, schizophrenia.
* P < .05, **P < .01, ***P < .001.