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. 2020 Aug 6;23(11):762–773. doi: 10.1093/ijnp/pyaa060

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© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Baicalein inhibited inflammasome dependent pyroptosis induced by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (A) Quantitative PCR analysis of mRNA relative expression of proinflammatory cytokines in brain substantia nigra (SN) tissue from indicated mice (n = 5/group). Data were normalized to a reference gene, Hprt. (B) ELISA analysis of protein expression of proinflammatory cytokines in brain SN tissue from indicated mice (n = 5/group). (C) Immune blotting analysis of NLRP3, caspase-1, and GSDMD (full-length and cleaved form) in the brain SN tissue from indicated mice (n = 3/group). Data are shown as representative plots (C) and quantified immunoblotting bands (D). (E–F) Flow-cytometric analysis of caspase-1⁺ PI⁺ cells from brain tissue (n = 3/group). Data are shown as representative plots (E) and quantified percentages (F). *P < .05, ^**P < .01, ^***P < .001 vs control group. ^#P < .05, ^##P < .01, ^###P < .001 vs MPTP group. Data are expressed as means ± SEM.