表 3.
EORA合并CVD与不合并CVD临床特征的差异
Clinical characteristics of EORA patients with or without CVD
| Items | CVD (n=59) | Without CVD (n=153) | Z/χ2 | P value |
| Data are presented as n (%) or median (P25, P75). Abbreviations as in Table 1 and Table 2. | ||||
| Male | 22 (37.3) | 46 (30.1) | 1.02 | 0.313 |
| Age/years | 74 (70, 78) | 70 (67, 75) | -3.12 | 0.002 |
| Disease duration/years | 4 (1, 8) | 2 (1, 5) | -1.83 | 0.068 |
| SJCs | 3 (1, 8) | 4 (1, 10) | -0.50 | 0.620 |
| TJCs | 6 (2, 15) | 6 (2, 17) | -0.77 | 0.444 |
| DJCs | 28 (47.5) | 51 (33.3) | 3.63 | 0.057 |
| ESR/(mm/h) | 47 (30, 65) | 43 (23, 71) | -0.36 | 0.716 |
| CRP/(mg/L) | 10.4 (2.8, 37.7) | 14.0 (1.8, 46.7) | -0.77 | 0.442 |
| DAS28-ESR | 4.6 (3.7, 5.7) | 4.5 (3.7, 5.8) | -0.47 | 0.636 |
| ≤2.6 | 6 (8.5) | 10 (6.5) | 0.81 | 0.369 |
| >2.6, ≤3.2 | 4 (6.8) | 11 (7.2) | 0.01 | >0.999 |
| >3.2, ≤5.1 | 29 (49.2) | 75 (49.0) | 0.00 | 0.986 |
| >5.1 | 20 (33.9) | 57 (37.3) | 0.21 | 0.649 |
| Rheumatoid factor (positive) | 14/49 (28.6) | 11/121 (9.1) | 10.55 | 0.001 |
| Anti-CCP antibody (positive) | 10/30 (33.3) | 13/79 (16.5) | 3.72 | 0.054 |
| Extra-articular manifestations | ||||
| Interstitial lung disease | 16 (27.1) | 34 (22.2) | 0.57 | 0.452 |
| Pleural effusion | 2 (3.4) | 1 (0.6) | 2.29 | 0.188 |
| Pericardial effusion | 1 (1.7) | 0 (0) | 2.606 | 0.278 |
| Rheumatoid nodules | 7 (11.9) | 6 (3.9) | 4.67 | 0.050 |
| Cutaneous vasculitis | 0 (0) | 1 (0.6) | 0.387 | >0.999 |
| Anemia | 10 (16.9) | 24 (15.7) | 0.050 | 0.822 |
| Peri-neuropathy | 0 (0) | 1 (0.6) | 0.387 | >0.999 |
| Sjögren's syndrome | 4 (6.8) | 7 (4.6) | 0.421 | 0.503 |
| Medications | ||||
| Non-DMARDs | 16 (27.1) | 59 (38.6) | 2.44 | 0.118 |
| Methotrexate | 9 (15.3) | 54 (35.3) | 10.09 | 0.004 |
| Hydroxychloroquine | 4 (6.8) | 35 (22.9) | 7.35 | 0.007 |
| Leflunomide | 25 (42.4) | 61 (39.9) | 0.11 | 0.739 |
| Sulfasalazine | 9 (15.3) | 40 (26.1) | 2.84 | 0.092 |
| Prednisone | 18 (3.1) | 32 (20.9) | 2.17 | 0.140 |
| Celecoxib | 2 (3.3) | 7 (4.6) | 0.15 | 0.701 |
| Biological agents | 3 (5.1) | 17 (11.1) | 1.81 | 0.179 |