表 1.
心脏/大血管受累BS患者的临床特征
Clinical characteristics of BS patients with cardiac/large vessel involvement
| No. | Age/Gender | Disease course/years | Systemic involvement | Vascular/cardiac manifestations, previous surgeries and postoperative complications | Previous treatment | Concomitant therapy | Operations (with perioperative GOL) | Duration of GOL treatment/months | Follow-up/months | Outcome |
| BS, Behcet syndrome; GOL, golimumab; M, male; F, female; O, oral aphthosis; G, genital aphthosis; S, skin involvement; P, positive pathergy test; A, arthritis; AR, aortic regurgitation; MR, mitral regurgitation; TR, tricuspid regurgitation; PVL, paravalvular leakage; GCS, glucocorticoid; CTX, cyclophosphamide; THD, thalidomide; COL, colchicine; TCZ, tocilizumab; AZA, azathioprine; T Ⅱ, tripterygium wilfordii; MTX, methotrexate; MMF, mycophenolate mofetil; LEF, leflunomide; MVR, mitral valve replacement; AVR, aortic valve replacement; TVP, tricuspid valvuloplasty. | ||||||||||
| 1 | 29/M | 5 | O, G, S | Abdominal aortic pseudoa-neurysm, superior mesenteric aneurysm, occlusion, stenosis of the abdominal trunk | GCS, CTX, THD | GCS, CTX, LEF, THD | Endovascular repair of aneurysm | 5 | 18 | No progression of vascular lesions |
| 2 | 37/M | 25 | O, G, S, P | Pulmonary aneurysm, pulmonary thrombosis, deep vein thrombosis of lower extremities | - | GCS, CTX | Pulmonary aneurysm packing + bronchial aneurysm embolization | 8 | 8 | Reduced size of aneurysms, no progression of vascular lesions |
| 3 | 35/M | 11 | O, G, S, A | AR, valvular vegetation-like mobile lesions, paravalvular abscess, stenosis of lower limb arteries | GCS, CTX, COL, THD, TCZ | GCS, CTX, AZA, COL | Bentall procedure + MVR | 23 | 23 | No PVL |
| 4 | 38/M | 10 | O, G, S | AR, paravalvular abscess | GCS, CTX | GCS, CTX | Bentall procedure | 17 | 17 | No PVL |
| 5 | 30/M | 1 | O, S | AR, aortic dissection, aortic dilation, aneurysm of aortic sinus | GCS, CTX, AZA, COL, T Ⅱ | GCS, CTX, AZA, T Ⅱ | Bentall procedure | 12 | 16 | No PVL |
| 6 | 34/M | 20 | O | AR, aortic dilation | GCS, CTX, THD | CTX, THD | None | 22 | 22 | Relieved aortic regurgitation, avoided surgical intervention |
| 7 | 57/F | 6 | O, G, S, A | AR, MR | - | GCS, CTX | AVR | 10 | 13 | No PVL |
| 8 | 31/M | 3 | O, S | AR, MR, TR, valvular ve-getation-like mobile lesions, aortic dilation, aneurysm of aortic sinus, post-cardiac operation, PVL | GCS, CTX, MTX, MMF, COL | GCS, CTX, MTX, MMF, COL | Bentall procedure | 8 | 8 | No PVL |
| 9 | 30/M | 10 | O, S | AR, MR, TR, paravalvular abscess, aortic dilation, post-cardiac operation, PVL twice | GCS, CTX, AZA, COL, THD | GCS, AZA, COL, THD | Bentall procedure + MVR + TVP | 6 | 21 | No PVL |