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. 2020 Dec 17;15:349. doi: 10.1186/s13023-020-01637-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Saccade performance left. a Main sequence with individual’s data points and 95% prediction interval (red solid lines) with statistics of peak saccade velocities obtained from readouts at given eye amplitudes (left and right lower panel) from the individual’s non-linear (V_max-V_max*exp(-A/A_c)) fit along the main sequence. b Saccade gain computed as the ratio of saccade amplitude and target amplitude. c Time duration from saccade onset to saccade end. d Response time as the time difference from target onset to saccade onset. Provided p-values resulted from Kruskal–Wallis analysis on ranks across groups, i.e. controls, Gaucher disease type 1 (GD-T1), Gaucher disease type 1 with R463C mutation (R463C), and Gaucher Disease type 3 (NGD). Statistically significant differences of post-hoc Dunn’s test are indicated by *p < 0.05; **p < 0.01; ***p < 0.001. All p-values are adjusted for multiple comparisons using the family-wise error rate