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. 2020 Dec 1;5(49):31706–31715. doi: 10.1021/acsomega.0c04220

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© 2020 American Chemical Society

This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.

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Concentration-response curves obtained with a BRET-based assay reporting the recruitment of β-arrestin to M1 receptors stimulated with various concentrations of indicated compounds (iperoxo-derived bitopic ligands (panel A), ACh-compounds (panel B), isoxazole-bitopic ligands (panel C), oxotremorine-M based ligands (panel D), and TMA-derived bitopic compounds (panel E)). β-Arrestin recruitment upon stimulation with saturating concentrations of carbachol (CCh) was set to 100%. Data are normalized to CCh and expressed as the means ± S.E.M. of 3–6 independent experiments performed in triplicate.