Table 2.
The affinities of TCR0 and TCR15 for the vrt1-pHLA and vrt0-pHLA*
| TCR no. | Ka (1/Ms) | Kd (1/s) | KD (M) | KD-TCR0/KD-TCR15 |
| Binding to the vrt1-pHLA | ||||
| TCR0 (WT) | 4.91E+05 | 2.68E+00 | 5.46E−06 | 1.0 |
| TCR15 | 4.19E+05 | 2.99E−01 | 7.14E−07 | 7.6 |
| Binding to the vrt0-pHLA | ||||
| TCR0 (WT) | 3.58E+05 | 7.76E−01 | 2.17E−06 | 1.0 |
| TCR15 | 4.28E+05 | 1.67E−01 | 3.90E−07 | 5.6 |
*The affinities of the TCRs were determined with Biacore 4000, and the change over the affinity of the wild-type molecule TCR0 is indicated.
pHLA, peptide-HLA complexes; TCR, T-cell receptor; WT, wild-type.