Table 1.
Reference | Study design | Participants characteristics | Experimental details | Outcome measures | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Neurological diagnosis | N | Age group | Concurrent medication | Stimulation type | Total stimulation time (min) | Current density (A/m2) | Concurrent task | Mean washout period (d) | Clinical outcome (description) | rsFC outcome | ||
De Ridder and Vanneste49 | Parallel | Fibromyalgia | A:19 | Adult | Yes | Bilateral | 300 | 0.429 | Nil | N/A | Symptomatic relief (pain perception) | EEG phase lagged index |
S:12 | ||||||||||||
Neeb et al50 | Parallel | Inflammatory bowel disorder | A:24 | Adult | Yes | Anodal | 100 | 0.571 | Nil | N/A | fMRI whole-brain rsFC | |
S:12 | ||||||||||||
Porcaro et al54 | Crossover | Multiple sclerosis | 13 | Adult | No | Anodal | 75 | Varied | Nil | Not stated | Symptomatic relief (fatigue perception) | EEG mutual information |
Mondino et al51 | Parallel | Schizophrenia | A:11 | Adult | Yes | Cathodal | 200 | 0.571 | Nil | N/A | Symptomatic relief (auditory hallucination) | fMRI seed-whole brain rsFC |
S:12 | ||||||||||||
Palm et al27 | Parallel | A:10 | Adult | Yes | Anodal | 200 | 0.571 | Nil | N/A | Symptomatic relief (psychiatric symptoms) | ||
S:10 | ||||||||||||
Shahbabaie et al53 | Crossover | Substance abuse | 15 | Adult | No | Bilateral | 20 | 0.571 | Nil | 7 | Symptomatic relief (drug craving intention) | fMRI whole-brain rsFC |
Sotnikova et al57 | Crossover | ADHD | 13 | Adolescent | Yes | Anodal | 20 | 0.769 | n-back task | 14 | Enhancement of specific neurological function (working memory performance) | fMRI seed-whole brain rsFC |
Cosmo et al58 | Parallel | A:30 | Adult | Not stated | Bilateral | 20 | 0.286 | Nil | N/A | N/A (only rsFC outcome measure were planned) | Weighted node degree | |
S:30 | ||||||||||||
Schoellmann et al55 | Crossover | Parkinson’s disease | 10 | Elderly | No | Anodal | 20 | 0.270 | Nil | Not stated | Enhancement of specific neurological function (motor function) | Imaginary corticocortical coherence |
Marangolo et al62 | Crossover | Stroke-induced aphasia | 9 | Adult | No | Bilateral | 300 | 0.571 | Syllable/word pronunciation training | 14 | Enhancement of specific neurological function (motor speech ability of trained items) | fMRI Eigenvector centrality |
Ficek et al56 | Parallel | Primary progressive aphasia | A:12 | Elderly | No | Anodal | 300 | 0.800 | Oral/written naming task training | N/A | Enhancement of specific neurological function (oral/written naming ability for trained and untrained items) | fMRI seed-seed rsFC |
S:12 | ||||||||||||
Lefebvre et al59 | Crossover | Stroke | 22 | Elderly | Not stated | Bilateral | 30 | 0.286 | Motor skill learning | N/A | Enhancement of specific neurological function (execution of learnt motor skill) | fMRI seed-whole brain rsFC |
Nicolo et al60 | Parallel | A:12 | Elderly | Not stated | Bilateral | 200 | 0.286 | Nil | N/A | Enhancement of specific neurological function (upper limb function) | Weighted node degree | |
S:12 | ||||||||||||
Thibaut et al61 | Crossover | Disorders of consciousness | 14 | Adult | Yes | Bilateral | 20 | Unknown | Nil | 2 | Enhancement of specific neurological function (spasticity) | EEG phase lagged index |
Wu et al63 | Parallel | A:5 | Adult | Yes | Anodal | 200 | 0.571 | Nil | N/A | Enhancement of global neurological function | Coherence | |
S:5 |
Abbreviations: A, active-tDCS; ADHD, attention-deficit/hyperactivity disorder; EEG, electroencephalography; fMRI, functional magnetic resonance imaging; N, number of participants; N/A, not applicable; rsFC, resting-state functional connectivity; S, sham-tDCS.