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. 2020 Nov 10;162(1):bqaa208. doi: 10.1210/endocr/bqaa208

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Figure 3. — Representative mRNA transcripts differentially expressed between ovaries and testes. Boxplots show median, upper, and lower quartiles, and the highest and lowest values of normalized mRNA expression in 29 gonads (y-axis shows normalized RNA-seq read counts per million mapped reads; cpm). Each panel shows 2 prototypical genes showing expression profiles represented by CYP19A1: modest but significant induction in FemZZs (A); ZP3: minimal induction in FemZZs (B); SEMA3C: robust induction in minimally converted FemZZs (C); D–J: CTNNB1: robust suppression in minimally converted FemZZs and involved in Wnt signaling (D), BMP signaling (E), pluripotency (F), myosin light chain expression and regulation (G), and collagen synthesis and regulation (H) (chromosomal locations shown in (I)) and miscellaneous pathways (J); and SKIV2L2: minimal suppression in genetic males and involved in gonadal sex differentiation and germline development (K), DNA repair (L), (maintenance of chromosomal structure (M), cytoskeleton (N), mitochondrial ribosomal formation (O), and miscellaneous pathways (P). Abbreviation: BMP, bone morphogenetic protein; DNA, deoxyribonucleic acid; mRNA, messenger ribonucleic acid.