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srebf1 S23fs mutation (c.68delG) established in zebrafish by CRISPR-Cas9. A: Genomic DNA sequence of adult zebrafish, wild type (WT), heterozygote (Het), and homozygote (knockout [KO]) for c.68delG, arrow indicating deletion point. B: RNA extraction from adult srebf1-/- show c.68delG in cDNA sequence. C: Schematic representation of srebf1 S23fs; deletion of Guanine (G) (indicated in red) generated a stop codon at locus 115 (codon 39).
