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. 2020 Dec 16;8(2):e001510. doi: 10.1136/jitc-2020-001510

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Antitumor vaccination elicited increased antibody responses over time, unlike androgen deprivation therapy (ADT). (A) The mean correlation coefficient among all pairs of different individuals (average pair) compared with the average correlation coefficient among all technical replicates (replicate) and the average correlation among samples collected from the same patient at different time points (same patient). Error bars represent SD. (B) Volcano plots depicting peptides to which there was increased signal following treatment with ADT or vaccine by at least twofold every 3 months, corresponding to a coefficient of time fixed-effect of 0.3333 (vertical line), and met the 5% Benjamini-Hochberg (BH) false discovery rate (FDR) cut-off using both Kenward Roger (KR) and Satterthwaite F-tests. Significant peptides are colored red. (C) Example box plots displaying log2 fluorescence levels for three peptides at baseline, 3 months and 6 months, in patients treated with ADT or vaccine. PAP, prostatic acid phosphatase.