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. 2020 Dec 16;8(2):e001510. doi: 10.1136/jitc-2020-001510

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Prostatic acid phosphatase (PAP)-targeted DNA vaccination causes similar increases in antibodies against proteins associated with nucleic acid binding and gene regulation in multiple patients. (A) Heatmap of the fluorescence residuals from the null model for each of the 5680 peptides that were significantly increased in vaccine-treated patients. Samples from vaccine-treated patients at each collection time point (baseline, 3 months and 6 months) are grouped together along the x-axis, while peptides are clustered along the y-axis. The order of the columns (patients) is consistent across the three timepoints for ease of comparison. (B) Waterfall plot of gene ontology (GO) analysis of proteins recognized more following vaccine.