Table 1:

Description of study population and hazard ratios (HR) from Cox univariate analysis for overall survival (OS).

	n (%)	HR	p-value
Age (years)
Mean (standard deviation)	56.9 (8.6)	1.018 (0.98–1.05)	0.2951
Gender
Male	254 (82)	1	Ref
Female	55 (17.8)	0.507 (0.21–1.21)	0.1242
Smoking Status
Never	128 (41.4)	1	Ref
Former	103 (33.3)	2.305 (0.94–5.64)	0.0673
Current	78 (25.2)	2.886 (1.40–5.95)	0.0041
Primary Site
BOT	105 (34)	1	Ref
Tonsil	197 (63.8)	0.921 (0.33–6.62)	0.8023
NOS	5 (1.6)	3.872 (1.10–13.61)	0.0347
Soft Palate	2 (0.6)	7.318 (0.94–57.10)	0.0576
Margins
Negative	255 (83)	1	Ref
Positive	54(18)	1.627 (0.82–3.25)	0.1672
Extranodal Extension
None	125 (48.4)	1	Ref
<1 mm	16 (6.2)	1.467 (0.33–6.62)	0.6178
>1 mm	117 (45.3)	1.818 0.91–3.62)	0.0886
Angiolymphatic Invasion
ALI+	172 (56)	1	Ref
ALI-	137 (44)	1.86 (0.95–3.64)	0.07
Perineural Invasion
PNI+	262 (85)	1	Ref
PNI-	47 (15)	1.944 (0.92–4.11)	0.0819
Treatment Type
Surgery Only	74 (23.9)	1	Ref
Surgery+Radiation (XRT)	102 (33)	1.205 (0.43–3.41)	0.7245
Surgery+Chemoradiation (CRT)	133 (43)	2.331 (0.88–6.15)	0.087
Decade of Surgery			0.2169
1980	8 (2.6)	2.6 (0.63, 0.16)	0.5138
1990	27 (8.7)	8.7 (1.79, 0.74)	0.1956
2000	29 (9.4)	9.4 (1.69, 0.69)	0.2512
2010	245 (79.3)	1.0	Ref