Dietary patterns with a higher inflammatory potential were significantly associated with a higher incidence of cardiovascular disease and subtypes, including coronary heart disease and stroke, in 3 prospective cohorts including 210,145 U.S. women and men and followed up for up to 32 years. Secondary analyses further showed that higher dietary inflammatory potential was significantly associated with biomarkers indicating higher systemic, vascular, and metabolic inflammation and an unfavorable lipid profile. The axis for hazard ratio is nature log-scaled with original labels.