Table 2.
Clusters for GM volume differences in HOA, KOA and healthy controls for whole brain analysis with and without brain flipping based on OA body side dominance (x-axis).
| Peak MNI coordinate region (Harvard-Oxford Cortical structural atlas) | Peak (max) F value | Number of voxels | Peak MNI coordinate |
|---|---|---|---|
| Non-flipped brain (Fig. 1C) | |||
| Paracingulate gyrus (20%); cingulate gyrus, anterior division (14%); juxtaposicional lobule cortex (7%) | 12.4 | 888 | (12,8,8) |
| Cingulate gyrus, anterior division (93%) | 8.58 | 51 | (−2,32,16) |
| Flipped brain (Fig 2.A) | |||
| Cingulate gyrus, anterior division (9%), posterior division (4%) | 18.8 | 1224 | (8,−8,32) |
| Precentral gyrus (54%) | 7.55 | 136 | (−28,−18,70) |
| Temporal pole (34%) | 9.06 | 122 | (34,8,−34) |
| Precuneous cortex (49%), intracalcarine cortex (72%) | 13.2 | 84 | (12,−58,10) |
| Middle frontal gyrus (42%), superior frontal gyrus (2%) | 10.3 | 76 | (30,24,50) |
| Middle frontal gyrus (23%), superior frontal gyrus (2%) | 8.45 | 30 | (−38,2,64) |
| Frontal orbital cortex (88%) | 10.5 | 27 | (−22,26,−20) |
| Heschl’s gyrus (22%) | 10.9 | 24 | (−42,−28,8) |
| Precentral gyrus (64%), middle frontal gyrus (2%) | 6.72 | 14 | (−52,−4,50) |
All identified clusters from VBM GLM analysis, TFCE uncorrected p<0.001. Cluster peak coordinates (x,y,z) are displayed according to MNI atlas, labels accordingly to the Oxford-Harvard Structural Cortical Atlas (http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Atlases). We accepted clusters greater than 66 voxels in size for post-hoc analysis, given the Gaussian Kernel (FWHM=8mm) used for smoothing.