Fig. 1. Self-regulation of HNF4α P1 proximal promoter by HNF4α.

(A) Effects of HNF4α on the reporter activities of HNF4A-P1 promoter with/without 5’ UTR in HEK293 cells. N=4, mean ± SE. * p<0.05 vs control group; (B) Real-time PCR quantification of HNF4A-P1–5’UTR mRNA in the presence/absence of HNF4α. N=3, mean ± SE; (C) Effects of HNF4α on the reporter activities of HNF4A-P1 promoter with/without 5’ UTR in HepG2 cells. in. N=4, mean ± SE. * p<0.05 vs control group; (D) Effects of HNF1α on the reporter activities of HNF4A-P1 promoter with/without 5’ UTR in HEK293 cells. N=4, mean ± SE. * p<0.05 vs control group.