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. Author manuscript; available in PMC: 2020 Dec 17.
Published in final edited form as: J Cell Biochem. 2018 Sep 7;120(1):519–532. doi: 10.1002/jcb.27407

Fig. 2. Bioinformatics studies indicate the correlation between HNF4A-AS1 and HNF4α.

Fig. 2.

(A) A schematic view of HNF4A/HNF4A-AS1 genomic structure and the construction principle of reporter vectors with HNF4A-AS1. Purple ellipse: HNF4A-P2 promoter; Purple rectangle: P2-exon1; Cyan arrows: The indicator of 5’ and 3` orientation. Blue ellipse: The proximal promoter of HNF4A-AS1; Blue rectangle: HNF4A-AS1 exons; Red arrow: coding sequence of HNF4A-AS1 proximal promoter. Green arrow: The reverse complementary sequence of red arrow; (B) The ChIP-seq data showing the binding of HNF4α to the promoter of HNF4A-AS1 and P1-HNF4A in liver and HepG2 cells.